NURS 6630 Foundational Neuroscience

NURS 6630 Foundational Neuroscience

Foundational Neuroscience

  1. Explain the agonist-to-antagonist spectrum of action of psychopharmacologic agents, including how partial and inverse agonist functionality may impact the efficacy of psychopharmacologic treatments.

Drugs possess two fundamental properties: affinity and intrinsic efficacy. Affinity refers to a drug’s capacity to attach itself to a receptor. Intrinsic efficacy refers to the ability of a drug to affect receptor activity, potentially inducing changes in cellular activity (Shiriaeva et al., 2022). The affinity and intrinsic efficacy of a drug-receptor pair are constant and distinct due to the receptor’s structure and the drug itself.  Agonists are pharmacological substances that bind to specific receptors, inducing changes in the receptor structure and triggering a physiological response (Miyachi, 2023). Antagonists or inverse agonists exhibit an opposing effect by failing to elicit a response upon binding to the receptor. A full agonist elicits its maximum response, while a partial agonist elicits only a partial or fraction of the response. A partial agonist can exhibit both agonistic and antagonistic properties due to its binding ability to specific molecules, resulting in minimal activity.

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  1. Compare and contrast the actions of g couple proteins and ion-gated channels.

GPCRs are a large family of receptors that utilize slower messenger systems (Hu et al., 2022). G proteins are utilized for intracellular signal transmission. Malfunctions of this receptor can lead to various disorders, as it plays a crucial role in numerous physiological functions within the human body. A distinct response is elicited when these proteins and their subunits interact with cellular proteins. G protein units are created through the binding of guanosine triphosphate. GTP is released and subsequently converted into GPD.

Ion-gated channels regulate the flow of ions across the cell membrane and play a crucial role in controlling neuronal firing (Shen et al., 2023). Upon ligand attachment, a channel is opened, facilitating the passage of specific ions. The formation of this channel occurs via the membrane-spanning region of the receptor. These channels play a crucial role in the functioning of the nervous system. Neurotransmitter messages are converted to electrical currents with the assistance of signaling mechanisms.

  1. Explain how the role of epigenetics may contribute to pharmacologic action.

Epigenetics refers to changes in genetic sequence that occur in addition to the primary genetic code (Ganesan et al., 2019).  Epigenetics encompasses mechanisms that modulate gene expression without altering the underlying DNA sequence. This biological process is inherent and essential for various organism functions. However, there are instances where abnormalities in this process can arise, resulting in significant health and behavioral complications. Cancer is a primary focus of epigenetic research. Various diseases, including cancer, exhibit distinct mutations that are challenging to detect and treat effectively, potentially resulting in cancer recurrence. Understanding epigenetic variations is crucial for effective disease treatment, as solely targeting one pathway may prove ineffective due to the involvement of multiple pathways. Treatment methods are influenced by alterations in cellular function resulting from epigenetic modifications.

  1. Explain how this information may impact how you prescribe medications to patients. Include a specific example of a situation or case with a patient in which the psychiatric mental health nurse practitioner must be aware of the medication’s action.

Understanding the biological mechanism and factors of a medication is crucial for PMHNPs when prescribing it to ensure effective treatment for the patient. Enhanced comprehension of brain function and dysfunction, specifically biological mechanisms, will facilitate the development of improved treatment modalities and medications. Selecting the most effective medication depends on the individual’s characteristics, family medical background, and genetic makeup (Phoenix, 2019). Cell behavior and interactions vary among individuals, leading to variations in cellular responses and, for instance, comparing the prescription of medications for depression in elderly patients versus young individuals. Another scenario involves the prescription of antipsychotic medication for pregnant women, as opposed to individuals who are not pregnant. These situations necessitate a high level of medication knowledge for PMHNPs when prescribing to diverse populations or individuals. Specific mutations in the TSH receptor lead to an increase in constitutive activity towards adenylyl cyclase. In addition to increasing the synthesis and release of thyroid hormone, activation of these receptors causes thyrocyte growth and proliferation. Modifications in these receptors may also lead to the development of malignancies concurrent with hypothyroidism.

 

References

Ganesan, A., Arimondo, P. B., Rots, M. G., Jeronimo, C., & Berdasco, M. (2019). The timeline of epigenetic drug discovery: from reality to dreams. Clinical Epigenetics11(1). https://doi.org/10.1186/s13148-019-0776-0

Hu, Y., Chen, M., Wang, M., & Li, X. (2022). Flow-mediated vasodilation through mechanosensitive G protein-coupled receptors in endothelial cells. Trends in Cardiovascular Medicine32(2), 61–70. https://doi.org/10.1016/j.tcm.2020.12.010

Miyachi, H. (2023). Structural Biology Inspired Development of a Series of Human Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Ligands: From Agonist to Antagonist. International Journal of Molecular Sciences24(4), 3940. https://doi.org/10.3390/ijms24043940

Phoenix, B. J. (2019). The Current Psychiatric Mental Health Registered Nurse Workforce. Journal of the American Psychiatric Nurses Association25(1), 38–48. https://doi.org/10.1177/1078390318810417

Shen, Z., Pu, S., Cao, X., Tang, M., Wang, S., Bai, D., & Jiang, G. (2023). Bioinformatics and network pharmacology analysis of drug targets and mechanisms related to the comorbidity of epilepsy and migraine. Epilepsy Research189, 107066. https://doi.org/10.1016/j.eplepsyres.2022.107066

Shiriaeva, A., Park, D., Kim, G., Lee, Y., Hou, X., Jarhad, D. B., Kim, G., Yu, J., Hyun, Y. E., Kim, W., Gao, Z.-G., Jacobson, K. A., Han, G. W., Stevens, R. C., Jeong, L. S., Choi, S., & Cherezov, V. (2022). GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A2A Adenosine Receptor. Journal of Medicinal Chemistry65(17), 11648–11657. https://doi.org/10.1021/acs.jmedchem.2c00462

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Foundational Neuroscience

As a psychiatric and mental health nurse practitioner, it is essential for you to have a strong background in foundational neuroscience. In order to diagnose and treat patients, you must not only understand the pathophysiology of psychiatric disorders but also how medications for these disorders impact the central nervous system. These concepts of foundational neuroscience can be challenging to understand. Therefore, this Discussion is designed to encourage you to think through these concepts, develop a rationale for your thinking, and deepen your understanding by interacting with your colleagues.

For this Discussion, review the Learning Resources and reflect on the concepts of foundational neuroscience as they might apply to your role as the psychiatric mental health nurse practitioner in prescribing medications for patients.

Resources

 

Be sure to review the Learning Resources before completing this activity.
Click the weekly resources link to access the resources.

WEEKLY RESOURCES

By Day 3 of Week 2

Post a response to each of the following:

  1. Explain the agonist-to-antagonist spectrum of action of psychopharmacologic agents, including how partial and inverse agonist functionality may impact the efficacy of psychopharmacologic treatments.
  2. Compare and contrast the actions of g couple proteins and ion gated channels.
  3. Explain how the role of epigenetics may contribute to pharmacologic action.
  4. Explain how this information may impact the way you prescribe medications to patients. Include a specific example of a situation or case with a patient in which the psychiatric mental health nurse practitioner must be aware of the medication’s action.

Upload a copy of your discussion writing to the draft Turnitin for plagiarism check.  Your faculty holds the academic freedom to not accept your work and grade at a zero if your work is not uploaded as a draft submission to Turnitin as instructed.

Read a selection of your colleagues’ responses.

By Day 6 of Week 2

Respond to at least two of your colleagues on two different days in one of the following ways:

  • If your colleagues’ posts influenced your understanding of these concepts, be sure to share how and why. Include additional insights you gained.
  • If you think your colleagues might have misunderstood these concepts, offer your alternative perspective and be sure to provide an explanation for them. Include resources to support your perspective.

Note: For this Discussion, you are required to complete your initial post before you will be able to view and respond to your colleagues’ postings. Begin by clicking on the Reply button to complete your initial post. Remember, once you click on Post Reply, you cannot delete or edit your own posts and you cannot post anonymously. Please check your post carefully before clicking on Post Reply!

 

 

NURS_6630_Week2_Discussion_Rubric

NURS_6630_Week2_Discussion_Rubric

Criteria Ratings Pts
This criterion is linked to a Learning Outcome Main Posting:Response to the Discussion question is reflective with critical analysis and synthesis representative of knowledge gained from the course readings for the module and current credible sources.
44 to >39.0 ptsExcellent Point range: 90–100

Thoroughly responds to the Discussion question(s)…. Is reflective with critical analysis and synthesis representative of knowledge gained from the course readings for the module and current credible sources…. No less than 75% of post has exceptional depth and breadth…. Supported by at least three current credible sources.

39 to >34.0 ptsGood Point range: 80–89

Responds to most of the Discussion question(s)…. Is somewhat reflective with critical analysis and synthesis representative of knowledge gained from the course readings for the module…. 50% of the post has exceptional depth and breadth…. Supported by at least three credible references.

34 to >30.0 ptsFair Point range: 70–79

Responds to some of the Discussion question(s)…. One to two criteria are not addressed or are superficially addressed…. Is somewhat lacking reflection and critical analysis and synthesis…. Somewhat represents knowledge gained from the course readings for the module…. Post is cited with fewer than two credible references.

30 to >0 ptsPoor Point range: 0–69

Does not respond to the Discussion question(s)…. Lacks depth or superficially addresses criteria…. Lacks reflection and critical analysis and synthesis…. Does not represent knowledge gained from the course readings for the module…. Contains only one or no credible references.

44 pts
This criterion is linked to a Learning Outcome Main Posting:Writing
6 to >5.0 ptsExcellent Point range: 90–100

Written clearly and concisely…. Contains no grammatical or spelling errors…. Adheres to current APA manual writing rules and style.

5 to >4.0 ptsGood Point range: 80–89

Written concisely…. May contain one to two grammatical or spelling errors…. Adheres to current APA manual writing rules and style.

4 to >3.0 ptsFair Point range: 70–79

Written somewhat concisely…. May contain more than two spelling or grammatical errors…. Contains some APA formatting errors.

3 to >0 ptsPoor Point range: 0–69

Not written clearly or concisely…. Contains more than two spelling or grammatical errors…. Does not adhere to current APA manual writing rules and style.

6 pts
This criterion is linked to a Learning Outcome Main Posting:Timely and full participation
10 to >8.0 ptsExcellent Point range: 90–100

Meets requirements for timely, full, and active participation…. Posts main Discussion by due date.

8 to >7.0 ptsGood Point range: 80–89

Posts main Discussion by due date…. Meets requirements for full participation.

7 to >6.0 ptsFair Point range: 70–79

Posts main Discussion by due date.

6 to >0 ptsPoor Point range: 0–69

Does not meet requirements for full participation…. Does not post main Discussion by due date.

10 pts
This criterion is linked to a Learning Outcome First Response:Post to colleague’s main post that is reflective and justified with credible sources.
9 to >8.0 ptsExcellent Point range: 90–100

Response exhibits critical thinking and application to practice settings…. Responds to questions posed by faculty…. The use of scholarly sources to support ideas demonstrates synthesis and understanding of learning objectives.

8 to >7.0 ptsGood Point range: 80–89

Response has some depth and may exhibit critical thinking or application to practice setting.

7 to >6.0 ptsFair Point range: 70–79

Response is on topic, may have some depth.

6 to >0 ptsPoor Point range: 0–69

Response may not be on topic, lacks depth.

9 pts
This criterion is linked to a Learning Outcome First Response:Writing
6 to >5.0 ptsExcellent Point range: 90–100

Communication is professional and respectful to colleagues…. Response to faculty questions are fully answered, if posed…. Provides clear, concise opinions and ideas that are supported by two or more credible sources…. Response is effectively written in Standard, Edited English.

5 to >4.0 ptsGood Point range: 80–89

Communication is mostly professional and respectful to colleagues…. Response to faculty questions are mostly answered, if posed…. Provides opinions and ideas that are supported by few credible sources…. Response is written in Standard, Edited English.

4 to >3.0 ptsFair Point range: 70–79

Response posed in the Discussion may lack effective professional communication…. Response to faculty questions are somewhat answered, if posed…. Few or no credible sources are cited.

3 to >0 ptsPoor Point range: 0–69

Responses posted in the Discussion lack effective communication…. Response to faculty questions are missing…. No credible sources are cited.

6 pts
This criterion is linked to a Learning Outcome First Response:Timely and full participation
5 to >4.0 ptsExcellent Point range: 90–100

Meets requirements for timely, full, and active participation…. Posts by due date.

4 to >3.0 ptsGood Point range: 80–89

Meets requirements for full participation…. Posts by due date.

3 to >2.0 ptsFair Point range: 70–79

Posts by due date.

2 to >0 ptsPoor Point range: 0–69

Does not meet requirements for full participation…. Does not post by due date.

5 pts
This criterion is linked to a Learning Outcome Second Response:Post to colleague’s main post that is reflective and justified with credible sources.
9 to >8.0 ptsExcellent Point range: 90–100

Response exhibits critical thinking and application to practice settings…. Responds to questions posed by faculty…. The use of scholarly sources to support ideas demonstrates synthesis and understanding of learning objectives.

8 to >7.0 ptsGood Point range: 80–89

Response has some depth and may exhibit critical thinking or application to practice setting.

7 to >6.0 ptsFair Point range: 70–79

Response is on topic, may have some depth.

6 to >0 ptsPoor Point range: 0–69

Response may not be on topic, lacks depth.

9 pts
This criterion is linked to a Learning Outcome Second Response:Writing
6 to >5.0 ptsExcellent Point range: 90–100

Communication is professional and respectful to colleagues…. Response to faculty questions are fully answered, if posed…. Provides clear, concise opinions and ideas that are supported by two or more credible sources…. Response is effectively written in Standard, Edited English.

5 to >4.0 ptsGood Point range: 80–89

Communication is mostly professional and respectful to colleagues…. Response to faculty questions are mostly answered, if posed…. Provides opinions and ideas that are supported by few credible sources…. Response is written in Standard, Edited English.

4 to >3.0 ptsFair Point range: 70–79

Response posed in the Discussion may lack effective professional communication…. Response to faculty questions are somewhat answered, if posed…. Few or no credible sources are cited.

3 to >0 ptsPoor Point range: 0–69

Responses posted in the Discussion lack effective communication…. Response to faculty questions are missing…. No credible sources are cited.

6 pts
This criterion is linked to a Learning Outcome Second Response:Timely and full participation
5 to >4.0 ptsExcellent Point range: 90–100

Meets requirements for timely, full, and active participation…. Posts by due date.

4 to >3.0 ptsGood Point range: 80–89

Meets requirements for full participation…. Posts by due date.

3 to >2.0 ptsFair Point range: 70–79

Posts by due date.

2 to >0 ptsPoor Point range: 0–69

Does not meet requirements for full participation…. Does not post by due date.

5 pts
Total Points: 100

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